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Increased serum levels of type IV collagen and laminin in a patient with a giant retroperitoneal schwannoma
Author(s) -
Iwahashi Masaaki,
Yamoto Mareo,
Yamashita Kazuya,
Nakano Ryosuke,
Ooshima Akira
Publication year - 1995
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1995.tb03458.x
Subject(s) - pathology , schwannoma , laminin , medicine , pathological , immunohistochemistry , type iv collagen , abdominal ultrasonography , staining , ultrasonography , radiology , biology , extracellular matrix , microbiology and biotechnology
A 63 year old woman presented with a giant abdominal tumor. Ultrasonography, computerized tomography and drop infused pyelography revealed a suspected retroperitoneal tumor. The tumor was removed surgically and weighed 2800g. The pathological diagnosis of the tumor was schwannoma. Strong immunohistochemical staining specific for type IV collagen and laminin was observed in the tumor, and these components were localized in the pericellular region of Schwann cells. The serum levels of these antigens, as determined by radio‐immunoassay, were very high before the operation but decreased rapidly thereafter.