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Histiocytoid cardiomyopathy with hypotonia in an infant
Author(s) -
Otani Masako,
Hoshida Hiroshi,
Saji Tsutomu,
Matsuo Norio,
Kawamur Sadao
Publication year - 1995
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1995.tb03396.x
Subject(s) - hypotonia , medicine , pathology , autopsy , cardiomyopathy , histiocyte , endocardium , cardiology , heart failure
A 15 month old fernate, who had suffered from ventricular tachycardia from the prenatal period, experienced cardiac arrest at home. Once she had recovered, ventricular tachycardia occurred rttpestedly. She died 7 months after admisskm. At autopsy, the heart showed many yellowish white nodub In the endocardium. Histologically these nodules consisted of granuiar or foamy histiocyte‐like cells, which had spread to all four chambers. Electron micrographs showed mitochowlrial hyperplasia in these cells. The cells had soate myofibrils in their cytoplasm. These findings were compatible wlth histiocytoid cardiomyopathy. Interestingly, the present case showed hypotonia. Her muscle biopsy revealed decreased activity of cytochrome c oxidBsB, sug‐ting that histiocytoid cardiomyopathy is related to mitochondriat cytopathy.