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Conversion of glomerular histology from a mesangiopathic to a membranopathic pattern in serum sickness nephritis with prolonged sensitization
Author(s) -
Yang Xiuying,
Nakazawa Koh,
Katoh Masahiro,
Itoh Nabuo,
Shigematsu Hidekazu
Publication year - 1995
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1995.tb03376.x
Subject(s) - sensitization , histology , nephritis , pathology , medicine , serum sickness , immunology , antibody
In order to examine the effect of prolonged sensitization on glomerular injury, serum sickness nephritis was induced in Fischer rats by administration of egg albumin (EA). Animals were divided into A, B and C groups with 4‐week, 6‐week and 6‐week sensitization, respectively. The experimental results were as follows: Both group A (4 weeks) and group B (6 weeks) showed mesangial immune complex deposition with proliferation (mesangiopathic pattern), but in the latter both the size and the amount of the deposits were larger than those in the former; while group C (8 weeks) demonstrated predominant distribution of deposition along the capillary walls (membranopathic pattern). It is suggested that such conversion of deposition from mesangiopathic to membranopathic pattern after prolonged repeated sensitization may be the result of the change of the host immune response to antigen, and for the character of the antibody.