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Overexpression of p53 protein and Ki67 proliferative index in hepatocellular carcinoma:
Author(s) -
D'Errico A.,
Grigioni W. F.,
Fiorentino M.,
Baccarini P.,
Grazi G. L.,
Mancini A. M.
Publication year - 1994
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1994.tb02947.x
Subject(s) - hepatocellular carcinoma , p53 protein , pathology , medicine , immunohistochemistry , gastroenterology , population , carcinoma , environmental health
The overexpression of p53 protein and the Ki67 proliferative index was evaluated in 96 hepatocellular carcinomas (HCC), 67 in cirrhotic livers and 29 in non‐cirrhotic ones, and in 13 non‐carcinomatous lesions, all surgically resected from Italian patients. Overexpression of p53 was detected only in carcinomatous lesions, and was significantly related to the grade of HCC ( P < 0.001). In fact, p53 was observed in 7/7 (100%) cases of grade IV, 13/43 (30.3%) of grade III, and 10/ 46 (21.7%) of grade II. The relationship between p53 and Ki67 scores was determined in serial sections from corresponding areas of both diffuse and patchy immunoreactivity. In the overall population, p53‐positive tumors showed a significantly higher Ki67 score (15.9 ± 5.5% vs 9.2 ± 4.3% [ P < 0.001]). This observation was evident in all grades of HCC.