Premium
Chromophobe renal cell carcinoma
Author(s) -
Fukushima Tadao,
Nagashima Yoji,
Nakatani Yukio,
Nakarnura Nobuko,
Fukasawa Kiyoshi,
Satomi Yoshiaki,
Yu Ken,
Miyagi Yohei,
Aoki Ichiro,
Misugi Kazuaki
Publication year - 1994
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1994.tb02942.x
Subject(s) - chromophobe cell , pathology , cytokeratin , peanut agglutinin , clear cell , vimentin , agglutinin , biology , renal cell carcinoma , cytoplasm , immunohistochemistry , oncocytoma , carcinoma , medicine , microbiology and biotechnology , lectin
Chromophobe renal cell carcinoma (RCC) is a recently established subtype of RCC, which has rarely been reported in Japan. In this communication, the authors report two Japanese cases of chromophobe RCC together with the immunohistochemical findings. The tumors were composed of sheets and cribriform glands formed by tumor cells with cloudy and reticular cytoplasm. Ultrastructurally, the cytoplasm was filled with numerous microvesicles. The tumor cells were positive for cytokeratin, epithelial membrane antigen, and Tamm‐Horsfall protein. Occasionally, LeuM1‐positive cells were also noted. Vimentin was negative, unlike the usual RCC. Reactivity for peanut agglutinin was more frequent than that to Lotus tetragonolobus agglutinin. The results of this study suggest that the tumor cellq possessed phenotypes similar to the distal nephron rather than to the proximal tubular cells.