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Mucosa‐associated lymphoid tissue (MALT) lymphoma of the stomach progressing to overt B cell malignancy
Author(s) -
Umemura Shinobu,
Tang Xiaoyan,
Aihara Hideo,
Tsutsumi Yutaka
Publication year - 1994
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1994.tb02931.x
Subject(s) - pathology , malignancy , malt lymphoma , lymphatic system , lymphoma , mucosa associated lymphoid tissue , stomach , medicine , gastric mucosa , biology
A 70 year old man, who underwent subtotal gastrectomy under the diagnosis of reactive lymphoid hyperplasia 6 years earlier, suffered from diffuse large‐cell‐type B cell lymphoma in the remnant stomach. Retrospectively reviewed, the initial lesion was consistent with mucosa‐associated lymphoid tissue (MALT) lymphoma, a low‐grade B cell malignancy, based upon histologic, cytologic and immunohistochemical features. Both the initial and recurrent tumors revealed the phenotypes of mantle zone cells, DBA4Cpositive. It is noteworthy that the overt lymphoma cells retained the capacity for inducing germinal center‐like nodules consisting of LN1 and DNA7‐positive cells even in the invading site. The diagnosis of reactive lymphoid hyperplasia of the stomach should be made after careful exclusion of the possibility of MALT lymphoma.