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Ciliated carcinoma of the endometrium associated with mucinous and neuroendocrine differentiation: A case report with immunohistochemical and ultrastructural study
Author(s) -
Motoyama Teiichi,
Ajioka Yoichi,
Ohta Tamaki,
Watanabe Hidenobu
Publication year - 1994
Publication title -
pathology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
eISSN - 1440-1827
pISSN - 1320-5463
DOI - 10.1111/j.1440-1827.1994.tb01714.x
Subject(s) - pathology , mucinous carcinoma , neuroendocrine differentiation , immunohistochemistry , adenocarcinoma , endometrium , mucin , enteroendocrine cell , carcinoma , endocrine system , ultrastructure , estrogen , biology , medicine , endocrinology , cancer , hormone , prostate cancer
A case of endometrial ciliated carcinoma mixed with foci of mucinous adenocarcinoma and argyrophil cells is described. The patient suffered from diabetes mellitus, hypertension and obesity, but had no history of estrogen use. Although the tumor presented well differentiated histologic features, it showed complete diffuse, endophytic extension. Approximately half of the cilia had abnormal inner structures, with 8 + 2 microtubular pattern. Some ciliated cells contained intracytoplasmic mucin, while others contained neurosecretory granules. These findings suggest that malignant ciliated cells have the capacity of further transformation into mucinous or endocrine cells.