Open AccessPrimary leiomyosarcoma of the thyroid gland
Author(s) -
Lida Yoji,
Katoh Ryohei,
Yoshioka Masakazu,
Oyarna Toshio,
Kawaoi Akira
Publication year - 1993
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1993.tb02917.x
Subject(s) - pathology , desmin , thyroid , cytokeratin , medicine , leiomyosarcoma , vimentin , carcinoembryonic antigen , thyroglobulin , immunohistochemistry , cancer
A primary leiomyosarcoma of the thyroid gland in a 72 year old Japanese woman is described. This is the second case reported in the English literature. The patient presented with a 7 month history of a gradually expanding tumor in the right neck. The surgical specimen taken by thyroid lobectomy revealed a relatively well demarcated tumor, 2X2X3 cm in size, confined to the right lobe. Histologically, the tumor showed a classical leiomyosarcomatous appearance of interlacing fascicles of spindle‐shaped cells with occasional blunt‐ended nuclei and a high frequency of mitotic figures. lmmunohistochemistry of the tumor cells clearly showed smooth muscle differentiation; the cells were positive for desmin, muscle‐specific action and vimentin and negative for cytokeratin, epithelial membrane antigen, carcinoembrionic antigen, thyroglobulin and calcitonin. The patient was free of disease for 3 years and 11 months without further treatment when evidence of multiple bone metastases appeared on bone scintigraphy. She died of pneumonia 4 years and 3 months after the lobectomy.