Open AccessPathological analysis of hypertrophic cardiomyopathy simulating dilated cardiomyopathy
Author(s) -
Kawashima Tetsuya,
Yokota Yoshiyuki,
Yokoyama Mitsuhiro,
Itoh Hiroshi
Publication year - 1993
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1993.tb02572.x
Subject(s) - hypertrophic cardiomyopathy , ventricle , medicine , cardiology , anterior wall , dilated cardiomyopathy , fibrosis , cardiomyopathy , pathological , anatomy , heart failure
The pathomorphologic features of hypertrophic cardiomyopathy simulating dilated cardiomyopathy in the late stage (HCM‐DCM) were compared with those of ordinary hypertrophic cardiomyopathy (HCM). Seven autopsied hearts with HCM‐DCM and 11 with HCM were assessed quantitatively using an image analyzer. Unlike HCM, significant left ventricular enlargement and wall thinning were observed in HCM‐DCM, and the percentage areas of massive fibrosis and disarray were significantly greater. In HCM‐DCM, the disarray was distributed diffusely, whereas massive fibrosis was distributed more intensively in the ventricular septum and anterior wall than in the lateral and posterior wall. Narrowing of intramyocardial small arteries was observed more frequently in HCM‐DCM, especially in the ventricular septum and anterior wall, than in HCM. These results suggest that the enlargement and wall thinning of the left ventricle in HCM‐DCM are attributable to non‐uniform progression of massive fibrosis, which is closely related to small‐arterial lesions.