Open AccessPrimary hepatic carcinoid tumor
Author(s) -
Yasoshima Hitoshi,
Uematsu Kunio,
Sakurai Kazunari,
Ueno Yuji,
Hori Kazutoshi,
Kanazawa Narimichi,
Tanaka Tsuneo,
Yamanaka Naoki,
Okamoto Eizo
Publication year - 1993
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1993.tb02567.x
Subject(s) - chromogranin a , pathology , histogenesis , periodic acid–schiff stain , enolase , staining , mucin , medicine , carcinoid tumors , primary tumor , biopsy , immunohistochemistry , metastasis , cancer
A case of primary carcinoid tumor arising in the liver of a 69 year old woman with no endocrine symptoms is reported. Histopathologically, the tumor was diagnosed initially as a hepatocellular carcinoma in the biopsy specimen, and was shown subsequently to be a carcinoid tumor, demonstrating diffuse positive staining with Grimelius method. Mucin stained with periodic acid‐Schiff (PAS), alcian‐blue, and mucicar‐mine, and was shown partially in the glandular structures. Immunohistochemically, most of the tumor cells stained positively for chromogranin‐A, epithelial membrane antigen (EMA) and neuron specific enolase (NSE). Ultrastructural examination revealed electron‐dense core granules, measuring 40‐120 nm in diameter in some of the tumor cells. Intensive and careful searches pre‐ and post‐operatively revealed no other primary source of tumor other than the liver. The patient was reported well with no symptoms 3 1 / 2 years after the operation.