Open AccessDistribution of laminin, type IV collagen and fibronectin in the invasive component of breast carcinoma
Author(s) -
Arihiro Koji,
Inai Kouki,
Kurihara Kanji,
Takeda Shinpei,
Kaneko Mayumi
Publication year - 1993
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1993.tb02563.x
Subject(s) - laminin , fibronectin , pathology , breast carcinoma , carcinoma , type iv collagen , stroma , estrogen receptor , metastasis , extracellular matrix , immunohistochemistry , lymph node , biology , medicine , breast cancer , cancer , microbiology and biotechnology
Laminin, type IV collagen and fibronectin were examined immunohistochemically in the invasive component of breast carcinomas. Laminin was expressed around the invasive carcinoma cell nests in 38 (54%) of 71 cases. Immunoreactiv‐ity for type IV collagen was observed around the invasive carcinoma cell nests or the stroma apart from carcinoma cells in 44 (80%) of 55 cases. Fibronectin was strongly expressed in the stroma only in 75 (99%) of 76 cases. The expression of laminin significantly correlated with tubular formation in the invasive carcinoma cell nests and showed a tendency to be correlative to estrogen receptor (ER) and progesterone receptor (PgR) of carcinoma tissue, but no correlation among laminin expression, histological type, the age of patients, tumor size and lymph node metastasis was noted. Type IV collagen and fibronectin did not correlate to any clinicopathological factors such as histological type, grade of differentiation, the age of patients, tumor size, lymph node metastasis, ER and PgR status. No concordant expression of these extracellular matrices was seen.