Open AccessEncapsulated papillary carcinoma of the thyroid gland: Clincopathological and cytoflurometric study in comparison with non‐encapsulated papillary carcinomy
Author(s) -
Oyama Tetsunari,
Ishida Tsunehiro,
Ishii Kaoru,
Sakurai Shinji,
Joshita Takashi,
Sakamoto Atsuhiko,
Nakajima Takashi
Publication year - 1993
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1993.tb01165.x
Subject(s) - papillary carcinoma , thyroid , pathology , medicine , carcinoma , thyroid carcinoma
Clinicopatholigical and cytofluroremetric studies were performed on nine encapsulated (EPC) and 23 non‐encapsulated (non‐EPC) carcinomas of the thyroid gland. The average age of the patients with EPC was 33 years, which was significantly younger than that of those with non‐EPC. The average tumor size of EPC was twice as large as that of intraglandular non‐escapsulated carcinoma. All patients with EPC were alive without disease, but three out of 23 patients with non‐EPC had a recurrence of the disease of died. Cytofluorometric studies showed that the mean nuclear DNA content and percentage of tumor cells in the S‐G2M phase of EPC were lower than that of non‐EPC. According to the DNA histogram pattern, all EPC showed distinct modal DNA values in the diploid or near diploid region of normal cells. However non‐EPC, especially extra‐glandular non‐encapsulated papillary carcinoma, showed a wide variety of DNA histogram patterns. The present study suggested that EPC is a distinct subtype of papillary carcinoma of the throid gland clinicopathologically and the cytofluorometrically it is differnt from non‐EPC.