Open AccessMixed gonadal dysgenesis: Endogenous hormonal effects in the endometrium and histogenesis of germinoma
Author(s) -
Motoyama Teiichi,
Tanikawa Toshitaka,
Watanabe Hidenobu
Publication year - 1993
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1993.tb01153.x
Subject(s) - gonadoblastoma , dysgerminoma , histogenesis , endometrium , gonad , biology , squamous metaplasia , estrogen , endocrinology , medicine , hormone , pathology , gonadal dysgenesis , germinoma , ovary , immunohistochemistry , epithelium , radiation therapy , biochemistry , gene , karyotype , chromosome
The clinicopathologic features of two patients with mixed gonadal dysgenesis are presented, with specific reference to the relationship between endogenous sex hormones and the endometrium and the development of neoplastic disease. One patient, whose immature gonad contained granulosa cells and theca cells, had elevated serum estrogen levels and an endometrium with frequent ciliated metaplasia and squamous metaplasia. Another patient had elevated serum testosterone levels and atrophic endometrium. Both had gonadal tumors, more specifically, germinomas, which contained many calcified nodules within the tumor. These findings suggest that these germinomas arose from a gonadoblastoma.