Open AccessAdenoendocrine cell carcinoma of the gallbladder: A histochemical and immunohistochemical study
Author(s) -
Ohmori Takaaki,
Furuya Keizo,
Okada Kazuyo,
Tabei Ryo,
Tao Shigeru
Publication year - 1993
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1993.tb01143.x
Subject(s) - chromogranin a , carcinoembryonic antigen , pathology , enteroendocrine cell , immunohistochemistry , cytokeratin , gallbladder , mucus , carcinoma , enterochromaffin cell , biology , endocrine system , medicine , cancer , serotonin , endocrinology , ecology , receptor , hormone
A case of adenoendocrine cell carcinoma of the gallbladder with adenomucous cells and neuroendocrine cells is report‐ ed. A histochemical and immunohistochemical study revealed that the primary tumor in the gallbladder was composed of mucus‐secreting and/or argyrophil cells. Furthermore, the tumor showed a positive reaction to carcinoembryonic antigen (CEA) in all tumor cells, to chromogranin A and cytokeratin in many tumor cells, to endocrine granule constituent (EGC) in some tumor cells, and to serotonin and somatostatin in a few tumor cells. In addition, a few mucous cells showed argyrophilia and EGC‐positivity in their cytoplasms. This case suggests that the adenoendocrine cell tumor is derived from endodermal stem cells as a result of bidirectional (exocrine and endocrine) differentiation.