Open AccessMorphometric analysis of gastric adenoma and well‐diferentiated adenocarcinoma as a basis for microscopic discrimination
Author(s) -
Sano Tomoaki,
Kondo Yoichiro,
Isono Kaichi
Publication year - 1993
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1993.tb01140.x
Subject(s) - pathology , adenoma , adenocarcinoma , gastric adenocarcinoma , basis (linear algebra) , medicine , cancer , mathematics , geometry
Morphometric analyses were performed on 11 cases of welldifferentiated gastric adenocarcinoma and six cases of gastric adenoma. The values for the mean nuclear area (A N ), the index for roundness of the nucleus (F x ), and the nucleus/cytoplasm ratio (N/C) were larger in the carcinoma group than in the adenoma group (P < 0.01; t‐test). The value of nuclear numerical density (N A ) was larger in the adenoma group than in the carcinoma group (P < 0.01; t‐test). There was an overlap between the N/C ratio in the carcinoma and adenoma groups. It was concluded that roundness and enlargement of the nucleus, and a low nuclear density are important prerequisites for distinguishing the common type of adenocarcinomas from adenomas. An additional mor‐phometric analysis was performed on seven cases of mucosal carcinoma. A three‐dimensional discriminant analysis using A N , F x and N A revealed that of these seven cases, three were consistent with the carcinoma group while one case was consistent with the adenoma group. The remaining three cases were judged as borderline.