Open AccessEBER‐1 expression in thymic carcinoma
Author(s) -
Fujii Takeshi,
Kawal Toshiro,
Saito Ken,
Fukushima Kanae,
Hasegawa Tsuguo,
Tokunaga Masayoshi,
Yokoyama Takeshi
Publication year - 1993
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1993.tb01118.x
Subject(s) - pathology , thymic carcinoma , medicine , biology , thymoma
The Epstein‐Barr virus‐encoded small nuclear RNA, EBER‐1, has been shown to be a suitable target for the in situ hybridization detection of EBV in routinely processed tissue specimens. We evaluated the presence of EBV in thymic carcinoma and invasive thymoma using EBER‐1 in situ hybridization on formalin‐fixed paraffin‐embedded tissue sections. EBER‐1 expression was demonstrated in a case of lymphoepithelioma‐like thymic carcinoma, but was not detectable in other thymic carcinomas including six squamous cell carcinomas, a clear cell carcinoma and seven invasive thymomas. As reported in three previous cases of EBV‐associated thymic carcinoma, lymphoepithelioma‐like thymic carcinoma was shown to be closely associated with EBV in our series.