Open AccessThree Human Osteosarcoma Cell Lines Exhibiting Different Phenotypic Expressions
Author(s) -
Hotta Tetsuo,
Motoyama Teiichi,
Watanabe Hidenobu
Publication year - 1992
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1992.tb03110.x
Subject(s) - osteosarcoma , alkaline phosphatase , pathology , extracellular , phenotype , in vitro , biology , cancer research , chemistry , microbiology and biotechnology , medicine , genetics , biochemistry , gene , enzyme
In an attempt to elucidate the differences in histological features and biological behavior of osteosarcomas, three human osteoblastic type osteosarcomas were studied in vitro and in nude mice. The secretory processing and extracellular fiber formation of type I collagen proved to be the most important factor in bone formation in the osteosarcomas. Alkaline phosphatase also seemed to be important. However, we were unable to find any particular protooncogene abnormalities which could have been implicated in the occurrence or biological behavior of these osteosarcomas. Acta Pathol Jpn 42: 595 603, 1992.