Open AccessAn Immunohistochemical and Ultrastructural Study of Case of Small‐cell Neuroendocrine Carcinoma in the Ampullary Region of the Duodenum
Author(s) -
Sarker Ashit Baran,
Hoshida Yoshihiko,
Akagi Seiji,
Hayashi Kazuhiko,
Murakami Ichiro,
Jeon Hou Jong,
Takahashi Kiyoshi,
Akagi Tadaatsu
Publication year - 1992
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1992.tb03101.x
Subject(s) - duodenum , ultrastructure , immunohistochemistry , pathology , neuroendocrine carcinoma , carcinoma , medicine , biology , anatomy
One case of small‐cell neuroendocrine carcinoma in the ampullary region of the duodenum is reported. The histological appearance of the tumor was identical to pulmonary small‐cell carcinoma. Neuroendocrine differentiation was demonstrated immunohistochemically by positive immunoreaction for neuron specific enolase, Leu 7 and chromogranin, and ultrastructurally by the presence of scanty dense core neurosecretory type granules. Small‐cell neuroendocrine carcinoma in the ampulla of Vater is extremely rare. To our knowledge, this is the sixth reported case.