Open AccessNodular Sclerosing Hodgkin's Disease Showing Positive Reaction for Anti‐IL 6/BSF2 Antibody
Author(s) -
Matsumoto Masahiro,
Aozasa Katsuyuki,
Ohsawa Masahiko,
Ikeda Hiroshi
Publication year - 1992
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1992.tb03089.x
Subject(s) - medicine , pathology , lymph node , lymph node biopsy , disease , lymph , biopsy , antibody , fever of unknown origin , immunology
A 53 year‐old man presented with bilateral cervical lymph node swelling and low fever. Swollen lymph node was biopsied, and diagnosed as nodular sclerosing Hodgkin's disease (HD). By combined radio‐ and chemotherapy, he went into complete remission. After 3 years, fever of 38 39.2 C and lymph node swelling appeared in the para aortic region and later became systemic. A biopsy was diagnosed as syncytial variant of HD with aid of immunohis‐tochemistry on frozen sections. Large atypical mono‐ or binucleated cells reacted with anti interleukin 6 (IL‐6) antibody. The patient's disease progressed with fever, and he died 66 months after the onset of disease. A previous biochemical study showed that IL‐6 displayed a real relation to the generation of fever. Therefore it is suggested that fever in this patient is related to IL‐6.