Open AccessJejunal Perforation Associated with Cytomegalovirus Infection in a Patient with Adult T‐Cell Leukemia‐Lymphoma
Author(s) -
Nabeshima Kazuki,
Sakaguchi Ei,
Inoue Shohei,
Eizuru Yoshito,
Minamishima Yoichi,
Koono Masashi
Publication year - 1992
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1992.tb02540.x
Subject(s) - medicine , cytomegalovirus , lymphoma , leukemia , perforation , adult t cell leukemia/lymphoma , cytomegalovirus infection , virology , immunology , t cell leukemia , human immunodeficiency virus (hiv) , herpesviridae , human cytomegalovirus , virus , viral disease , punching , materials science , metallurgy
A patient with adult T‐cell leukemia lymphoma suffered a jejunal perforation, which we believe was directly attributable to cytomegalovirus (CMV) infection. In the areas of ulceration and perforation in the small bowel, blood vessels penetrating the muscularis propria showed extensive lining of cytomegalic endothelial cells with CMV inclusions, accompanied by occasional disruption of the walls, partial occlusion of the lumina, fibrin thrombi, and hemorrhage. The CMV‐induced vascular damage seemed to be closely related to the occurrence of ulcers and perforation. The recognition of CMV as a cause of lethal gastrointestinal lesions in immunocompromised hosts has become more important with the advent of anti CMV therapy. Acta Pathol Jpn 42: 267 271, 1992.