Open AccessA Case of Intramural Uterine Stromal Tumor with EpitheliaI Differentiation
Author(s) -
Masunaga Atsuko,
Oka Teruaki,
Nakamura Hisayoshi,
Kinoshita Katsuyuki,
Yamashita Tomoyuki,
Sugawara Isamu,
Itoyama Shinji
Publication year - 1992
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1992.tb01899.x
Subject(s) - cytokeratin , stromal cell , vimentin , pathology , immunohistochemistry , stromal tumor , endoplasmic reticulum , cd34 , uterine fibroids , biology , medicine , stem cell , microbiology and biotechnology
A case of intrauterine tumor in a 62 year old Japanese woman is presented. It was thought initially that this was a case of uterine tumor resembling an ovarian sex cord tumor. To examine the cytological features of the tumor cells, electron microscopical and immunohistochemical studies were done, and a hormone assay of the tumor tissue was performed. The tumor cells were rich in rough endoplasmic reticulum (rER), mitochondria and microfila‐ments. Some tumor cells tended to form glandular patterns, but these epithelial elements were frequently scattered among fibrous stromal elements. Though many tumor cells with an epithelial appearance possessed a large quantity of cytokeratin and vimentin, they did not secrete estradiol, progesterone, testosterone or human chorionic gonadotropin. This case was finally diagnosed as an intramural uterine stromal tumor with epithelial differentiation after taking all the available data into consideration. This would be classified as an endometrial stromal tumor with epithelial elements, recently proposed and named by Clement and Scully. Acta Pathol Jpn 42: 916–922, 1992.