Open AccessThe Presence of Immunoreactive Parathyroid Hormone‐related Protein in Parathyroid Adenoma Cells
Author(s) -
Matsushita Hiroshi,
Hara Mitsuru,
Nakazawa Hideki,
Shishiba Yoshimasa,
Matuhasi Tyoku
Publication year - 1992
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1992.tb01108.x
Subject(s) - parathyroid hormone , parathyroid adenoma , adenoma , parathyroid neoplasm , parathyroid hormone related protein , pathology , parathyroid chief cell , medicine , calcium
Parathyroid hormone‐related protein (PTHrP) was first identified in human malignant tumors associated with humoral hypercalcemia of malignancy. We immunohisto‐chemically examined the distribution of PTHrP both in 7 normal parathyroid glands and in 20 parathyroid adenomas. Sixty five percent of parathyroid adenomas (13 cases) were positive for PTHrP, whereas only one normal parathyroid gland was positive for PTHrP in the area of transitional oxyphil cells. Many parathyroid adenomas (12 cases) were composed of both PTHrP positive cells and ‐negative cells, and these two different type of cells showed a tendency to form nodules respectively in parathyroid adenoma. Although both chief cells and oxyphil or transitional oxyphil cells were positive for PTHrP in parathyroid adenoma, oxyphil or transitional oxyphil cells were more responsible for PTHrP production than chief cells. Chief cells are thought to produce parathyroid hormone mainly in parathyroid adenoma. On the other hand, little is known concerning the function and role of oxyphil or transitional oxyphil cells. Our results suggest that oxyphil or transitional oxyphil cells in parathyroid adenoma may have some functional roles different from those of chief cells through the production of PTHrP.