Open AccessA Light and Electron Microscopical Study of Membranocystic Lesions in a Case of Lupus Erythematosus Profundus
Author(s) -
Kuwabara Hiroko,
Uda Hirotsugu,
Saito Katsuhiro
Publication year - 1991
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1991.tb03357.x
Subject(s) - pathology , basement membrane , thickening , anatomy , immunofluorescence , subcutaneous tissue , lupus erythematosus , medicine , electron microscope , chemistry , antibody , physics , polymer science , optics , immunology
A light and electron microscopical study on membranocys‐tic lesions (MCL) in a case of lupus erythematosus profundus (LEP) is reported. The patient was a 16 year old female who presented with subcutaneous nodules on both upper arms. The light microscopic features were consistent with LEP, and the result of an immunofluorescence band test supported this diagnosis. A peculiar finding in this case was MCL in the subcutaneous tissue. Ultra‐structurally, these were thin membranes without a tubular structure and tortuous thick membranes composed of minute tubules. The lesions were very similar to the fatty tissue changes in membranous lipodystrophy. On the other hand, the basement membranes of the blood vessels were thickened and multilayered, and the Iumina were narrowed by endothelial swelling and thickening of the vessel wall. Our findings suggest that the MCL in LEP result from circulatory disturbance of the fat tissue.