Open AccessMyxoid Leiomyosarcoma of the Kidney Accompanying Ipsilateral Ureteral Transitional Cell Carcinoma: A Case Report with Cytological, Immunohistochemical and Ultrastructural Study
Author(s) -
Yokose Tomoyuki,
Fukuda Hiroshi,
Ogiwara Akira,
Sakai Kunihiko,
Saitoh Kiyoshi
Publication year - 1991
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1991.tb02795.x
Subject(s) - pathology , transitional cell carcinoma , leiomyosarcoma , urine cytology , renal pelvis , medicine , desmin , ureter , vimentin , immunohistochemistry , cancer , cystoscopy , urology , alternative medicine , bladder cancer
The authors report a case of myxoid leiomyosarcoma of the kidney accompanying ipsilateral ureteral transitional cell carcinoma. A 74‐year‐old male patient complained of turbid urine and macroscopic hematuria. He also complained of left back pain, appetite loss and weight loss. Computed tomography revealed a large mass in the left retroperitoneum. Urine cytology disclosed two types of malignant cells, atypical spindle‐shaped cells and transitional cell carcinoma. Left total nephro‐ureterectomy was performed. The left kidney was occupied by a 6X4X4 cm, multinodular and mucinous tumor. A transitional cell carcinoma of the left ureter was also observed. The renal tumor was composed of atypical spindle‐shaped cells in the mucinous stroma, which showed positive immunoreactivity for anti‐muscle‐specific actin and anti‐desmin antibodies. The ultrastructural examination revealed intracytoplasmic microfilaments with dense bodies, pinocytotic vesicles and junctional structure. These findings were suggestive of the myogenic feature of the case. Urine cytology revealed a number of sarcoma cells in this case since the sarcoma cells markedly invaded the renal pelvis and were apt to separate individually in myxoid stroma. Simultaneous and ipsilateral double malignancies of the renal sarcoma and ureteral transitional cell carcinoma have never been reported in the literature. Acta Pathol Jpn 41: 694–700, 1991.