Open AccessFocal Segmental Glomerular Hyalinosis and/or Sclerosis in Rats with Congenital Unilateral Hydronephrosis
Author(s) -
Ishitobi Fumio,
Sagiya Atsushi,
Oka Kazuo,
Ueda Yoshihiko,
Takimoto Toshiro,
Ono Yuko,
Kanaya Hiroaki,
Yaguchi Tadashi,
Lidaka Kazunari,
Tauchi Kiyonori
Publication year - 1991
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1991.tb02788.x
Subject(s) - hydronephrosis , pathology , medicine , glomerulosclerosis , kidney glomerulus , kidney , immunoperoxidase , proteinuria , anatomy , glomerulonephritis , antibody , urinary system , immunology , monoclonal antibody
Focal segmental glomerular hyalinosis and/or sclerosis (FSHS) was observed in five Wistar‐Imamichi rats with congenital unilateral hydronephrosis (CUH rats). Marked proteinuria (164.9+138.4mg/day) was observed in the CUH rats. Immunoperoxidase staining for IgM, C3 and IgG was positive in the glomerull, showing in a focal, segmental pattern that corresponded to the areas of FSHS seen by light microscopy. These glomerular findings were extremely similar to those of human focal glomerular sclerosis (FGS). FSHS was found to be common to both the hydronephrotic kidney and the contralateral kidney without hydronephrosis. Morphometry revealed that the glomerular area of the juxtamedullary glomeruli was greater than that of superficial glomeruli in control rats (11,037 μm 2 vs. 6,847 μm 2 ). On the other hand, glomerular hypertrophy was observed in non‐sclerotic glomeruli of CUH rats (superficial glomeruli; 12,477–16,123 μm 2 , juxtamedullary glomeruli; 14,635–18,418 μm 2 ). Also, a decreased in the number of glomeruli within the range 1.8‐4.1 per unit area (1 mm 2 ) was seen in CUH rats compared with control rats (mean 4.4). These results suggest that the increased rate of development of FSHS is based on hyperfiltration in the remaining functional nephrons. Acta Pathol Jpn 41: 653–660, 1991.