Open AccessA Case of Malignant Duct‐Islet Cell Tumor of the Pancreas Immunohistochemical and Cytofluorometric Study
Author(s) -
Kashiwabara Kenji,
Nakajima Takashi,
Shinkai Hiroko,
Fukuda Toshio,
Oono Yoshihiro,
Kurabayashi Yuichi,
Kojima Takahiro,
Nagamachi Yukio
Publication year - 1991
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1991.tb02533.x
Subject(s) - pathology , immunohistochemistry , pancreas , islet , medicine , duct (anatomy) , insulin
A rare duct‐islet cell tumor of the pancreas was studied using immunohistochemical, cytofluorometric and histo‐chemical methods. Histology and immunohistochemistry revealed that the tumor contained two distinct cell types; islet cell‐like neuroendocrine cells and exocrine duct cell components, suggesting an endodermal origin for both types. The cells showed marked pleomorphism and vascular and perineural invasion at the tumor periphery. Cytofluorometric study of the tumor cell DNA revealed an increased mean nuclear DNA content, without any aneuploidy. Histochemically, the tumor cells contained an increased number of argyrophilic nucleolar organizer regions (AgNORs) in their nuclei. The malignant potential of this duct‐islet cell tumor was suggested. Acta Pathol Jpn 41: 636‐641, 1991.