Open AccessUnusual Pancreatic Tumor Resembling Solid and Cystic Tumor, with Somatostatin Production and Aberrant Crystalloid Structures
Author(s) -
Kakihara Toshio,
Fukuda Takeaki,
Nemoto Keiichi,
Ohnishi Yoshihisa,
Kusama Katsuhiro
Publication year - 1991
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1991.tb02532.x
Subject(s) - pathology , somatostatin , pancreas , pancreatic tumor , tumor cells , electron microscope , endocrine system , enteroendocrine cell , biology , chemistry , medicine , pancreatic cancer , endocrinology , cancer research , cancer , physics , hormone , optics
An unusual pancreatic tumor in a middle‐aged man is reported. The tumor was a large encapsulated mass with necrosis and hemorrhage, and microscopically, it showed a predominant microcystic pattern with solid pattern areas. The clinical and histological features of this tumor were similar to those of solid and cystic tumor. Immunohisto‐chemical studies showed that the tumor was positive for ax‐AT, NSE, CA 19 9 and somatostatin. Electron microscopy studies showed neurosecretory granules, intercellular junctions, annulate lamellae and aberrant crystalloid structures. These findings indicated that the tumor had differentiated into acinar, ductal and endocrine cells, suggesting that solid and cystic tumor originates from multipotential immature cells. Acta Pathol Jpn 41: 629‐635, 1991.