Open AccessImmunohistochemical Observation of Recovery of the Periarteriolar Lymphoid Sheath, Lymph Follicle and Marginal Zone in the 60 Co‐irradiated Spleen of Rats
Author(s) -
Satoh Takashi
Publication year - 1991
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1991.tb02525.x
Subject(s) - marginal zone , spleen , lymphatic system , pathology , immunoglobulin d , lymph , immunohistochemistry , lymph node , biology , follicular dendritic cells , chemistry , medicine , anatomy , antibody , immunology , immune system , b cell , antigen presenting cell , t cell
After 60 Co irradiation of rat spleen, the most severe damage was found initially in the lymph follicles (LFs); lymphocytes were decreased in number in the periarteriolar lymphoid sheath (PALS), and almost completely depleted in the marginal zone (MZ). Recovery was observed first in the PALS, followed by the LFs, and finally the MZ. From the results of immunohistochemistry, the process of recovery was assumed to involve migration of T and B lymphocytes along the arterioles from the area surrounding the terminal arteriole at the end of the PALS into the central part of the PALS and into the LF. Peripheral blood lgM + , IgD − B lymphocytes, known to be MZ precursor cells, flowed from the follicular artery to settle in the MZ. Furthermore, recovery of the PALS prior to the LFs was suggested to be essential for lymphocyte migration to the LFs. Acta Pathol Jpn 41: 581‐589, 1991.