Open AccessMalignant Islet Cell Tumor of the Pancreas with Multiple Hormone Production and Expression of CEA and CA19‐9
Author(s) -
Arihiro Koji,
Inai Kouki
Publication year - 1991
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1991.tb02510.x
Subject(s) - islet , pancreas , ca19 9 , pathology , hormone , medicine , cancer research , biology , pancreatic cancer , insulin , cancer
An autopsy case of malignant islet cell tumor of the pancreas is presented. The patient, a 64 year old woman showed severe hypoglycemia as the initial symptom, and hyperinsulinemia was demonstrated by laboratory examinations. Metastatic tumors in the liver were found by abdominal computed tomography. Autopsy revealed a tumor measuring 6.5x3x2cm occupying the pancreas from the body to the tail. From the results of histological and immunohistochemical studies, this was diagnosed as a malignant islet cell tumor producing multiple hormones such as insulin, glucagon, somatostatin and pancreatic polypeptide, as well as expressing the tumor‐related antigens CEA and CA19‐9. These findings suggested that the tumor cells showed differentiation to both endocrine cells and pancreatic duct cells. Acta Pathol Jpn 41: 150‐157, 1991.