Open AccessAlpha‐fetoprotein‐producing Papillary Adenocarcinoma Originating from a Uterine Body A Case Report
Author(s) -
Kubo Kiyoko,
Lee GangHong,
Yamauchi Kazuhiro,
Kitagawa Tomoyuki
Publication year - 1991
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1991.tb01665.x
Subject(s) - histogenesis , pathology , papillary adenocarcinoma , yolk sac , adenocarcinoma , ovary , immunohistochemistry , alpha fetoprotein , medicine , carcinoma , serous fluid , biology , cancer , hepatocellular carcinoma , embryo , microbiology and biotechnology
A rare case of alpha fetoprotein (AFP) producing papillary adenocarcinoma originating from the uterine body of a 55‐year‐old Japanese woman is reported. The histologic appearance of the tumor was reminiscent of a serous papillary carcinoma of the ovary, in clear contrast to that of common endometrial adenocarcinomas. No features of embryonal carcinoma or yolk sac tumor were evident. Immunohistochemical examination demonstrated the production of AFP by the tumor cells. To our knowledge there are six reported cases of AFP producing malignant tumors of the uterine body in the literature, four of them being yolk sac tumor, one mixed mesodermal tumor, and one endometrial adenocarcinoma. This is therefore the first case of an AFP producing papillary adenocarcinoma that developed in the uterine body. This report should contribute to a better understanding of the histogenesis of AFP producing tumors in this organ.