Open AccessMultiple Pulmonary Hyalinizing Granulomas Associated with Systemic Idiopathic Fibrosis
Author(s) -
Kuramochi Shigeru,
Kawai Takeshi,
Yakumaru Kazuhiro,
Mikata Atsuo,
Torikata Chikao,
Kasuga Yoshio,
Fujiwara Tatsuji
Publication year - 1991
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1991.tb01661.x
Subject(s) - medicine , pathology , fibrosis , hyaline , lung , autopsy , thyroid , retroperitoneal fibrosis , pulmonary fibrosis , idiopathic pulmonary fibrosis
A 41 year‐old man with progressive nodular infiltration of the lung of about 2 years’duration died of cardiac and respiratory failure. Autopsy revealed bilateral multiple pulmonary hyalinizing granulomas (PHGs) diagnosed on the basis of the characteristic dense hyaline collagen bundles with nonspecific inflammatory infiltration. Constrictive pericarditis, retroperitoneal fibrosis, mediastinal fibrosis, fibrous thickening of the peritoneal and pleural surfaces, and fibrosis of soft tissue of the neck, flank, and hepatic hilar region were present, therefore, a diagnosis of systemic idiopathic fibrosis was made. The patient had anti thyroglobulin and anti‐thyroid microsomal antibodies and lymphocytic thyroiditis. The inflammatory process of PHG of the present case was active and the clinical course was progressive. PHG seems to be a lesion belonging to the systemic idiopathic fibrosis complex. Immunologic abnormalities may be related to PHG and systemic idiopathic fibrosis.