Open AccessMonocytoid B Lymphocytes and Epithelioid Cell Clusters in Abscess‐forming Granulomatous Lymphadenitis With Special Reference to Cat Scratch Disease
Author(s) -
Kojima Masaru,
Hosomura Yasuo,
Itoh Hideaki,
Johshita Takashi,
Ohno Yoshihiro,
Yoshida Katsue,
Asano Shigeyuki,
Wakasa Haruki,
Nakamura Shigeo,
Suchi Taizan
Publication year - 1991
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1991.tb01659.x
Subject(s) - cat scratch disease , pathology , epithelioid cell , abscess , medicine , disease , immunohistochemistry , surgery
In order to clarify the appearance of monocytoid B lymphocytes (MBLs) in abscess‐forming granulomatous lymphadenitis (AGL) and the relation between AGL and cat‐scratch disease (CSD), 48 cases of AGL were studied histologically. MBLs were present in about 50% of AGL cases. Warthin Starry (WS) silver stain‐positive bacteria, which are the causative agent of CSD, were present in 52.4% of AGL cases with MBLs and 59.2% of AGL cases without MBLs. The appearance of MBLs in AGL was not related to various clinical features, including disease interval from initial lymphadenopathy to lymph node biopsy. Histologically, epithelioid cell clusters appeared in about 70% of MBL positive AGL cases, but were not observed in MBL negative AGL. Therefore, a close interaction between MBLs and epithelioid cells in AGL is suggested, and we emphasize that the histological features of some AGL cases resemble those of toxoplasmic lymphadenitis.