Open AccessImmunohistochemical Characterization of Human Cutaneous Mast Cells in Urticaria Pigmentosa (Cutaneous Mastocytosis)
Author(s) -
Akiyama Masashi,
Watanabe Yonosuke,
Nishikawa Takeji
Publication year - 1991
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1991.tb01657.x
Subject(s) - urticaria pigmentosa , cutaneous mastocytosis , immunohistochemistry , pathology , medicine , dermatology , systemic mastocytosis , disease
To clarify the origin and function of human cutaneous mast cells (CMCs), immunohistochemical characterization was done in 19 cases of urticaria pigmentosa (cutaneous mastocytosis) using 9 antibodies (anti leukocyte common antigen, MX‐PanB, anti lysozyme, anti α 1 , antitrypsin, anti α 1 ‐antichymotrypsin, anti vimentin, anti‐neuron specific enolase, anti factor VIII related antigen, and anti‐ACTH). CMCs showed positive reactions with anti α 1 anti‐chymotrypsin and anti vimentin in almost all of the specimens. In more than half of the specimens, CMCs were stained positively with anti ‐α 1 ‐antitrypsin, MX‐PanB, and anti factor VIII related antigen. Anti‐leukocyte common antigen and anti ACTH also showed positive reactions in some specimens. These results confirm the existence of vimentin filaments in CMCs and suggest a functional role of CMCs in hemostasis via factor VIII. Furthermore, immunohistochemical similarity between CMCs and granulocyte/macrophage group cells is also suggested.