Open AccessS‐100 Protein in Ovarian Tumors
Author(s) -
Lin Meisui,
Hanai Jun,
Wada Akira,
Ozaki Masami,
Nasu Kenji,
Okamoto Shigeru,
Matsumoto Keishi
Publication year - 1991
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1991.tb01653.x
Subject(s) - serous fluid , carcinoembryonic antigen , pathology , ovary , immunohistochemistry , antigen , ovarian tumor , biology , medicine , cancer research , ovarian cancer , cancer , immunology
The distribution of S 100 protein in 135 ovarian tumors, of which 127 were epithelial, was investigated using the im‐munoperoxidase method. S 100 protein has been demonstrated previously in tumors of various origins. The present study further revealed its characteristic distribution in common epithelial tumors of the ovary. S 100 protein was present in 69% of serous tumors (benign, 50%; borderline, 100%; malignant, 71%), as well as in the serous elements of serous & mucinous mixed tumors (30%). S 100 protein was also demonstrated in 25% of clear cell carcinomas and 29% of endometrioid carcinomas. Interestingly, none of the mucinous tumors were positive for S 100 protein. In addition, the expression of S‐100 protein by epithelial ovarian tumors was compared with that of CA 125 and carcinoembryonic antigen (CEA). The distribution of S 100 protein was similar to that of CA 125, since both antigens were frequently present in serous tumors, although their expression patterns were different. On the other hand, S 100 protein positive cases were almost negative for CEA or vice versa. Our observations indicate that demonstration of S 100 protein in common epithelial tumors of the ovary and comparison of S‐100 protein distribution with that of CA 125 and CEA may further clarify the characteristics of common epithelial tumors of the ovary.