Open AccessPathological Features of Virus Infections of the Central Nervous System (CNS) in the Acquired Immunodeficiency Syndrome (AIDS)
Author(s) -
Hall William W.,
Farmer Peter M.,
Takahashi Hidehiro,
Tanaka Shinya,
Furuta Yasushi,
Nagashima Kazuo
Publication year - 1991
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1991.tb01644.x
Subject(s) - papovavirus , progressive multifocal leukoencephalopathy , virology , herpes simplex virus , virus , cytomegalovirus , leukoencephalopathy , medicine , opportunistic infection , immunodeficiency , jc virus , pathological , human immunodeficiency virus (hiv) , immunology , biology , pathology , viral disease , herpesviridae , disease , immune system
Neurological disorders are a common cause of morbidity and mortality in the acquired immunodeficiency syndrome (AIDS). In this report we describe the neuropathological changes associated with both human immunodeficiency virus (HIV) infection and with the major opportunistic virus infections, cytomegalovirus (CMV), JC papovavirus (JCV) and herpes simplex virus (HSV) seen in AIDS. In addition “in situ” hybridization studies have been employed for the detection of virus genomic material in each case and the usefulness of this method in supporting the pathological diagnosis is demonstrated. Mechanisms whereby HIV infection results in leukoencephaiopathy and the possible contributing roles of the three opportunistic virus infections are discussed.