Open AccessOPD4–positive T–cell Lymphoma of the Liver in Systemic Lupus Erythematosus
Author(s) -
Tsutsumi Yutaka,
Deng Yinlong,
Uchiyama Mitsuaki,
Kawano Koichi,
Ikeda Yasuo
Publication year - 1991
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1991.tb01626.x
Subject(s) - medicine , lymphoma , pathology , extramedullary hematopoiesis , spleen , bone marrow , autoimmune hemolytic anemia , autopsy , lesion , biopsy , anemia , haematopoiesis , immunology , biology , stem cell , genetics
Primary malignant lymphoma of the liver occupying the right lobe, 14x9x7 cm in size, developed in a 30‐year‐old man with a 4‐year history of autoimmune hemolytic anemia. The diagnosis of systemic lupus erythematosus (SLE) accompanying thrombocytopenia had been made clinically 10 months earlier. The liver biopsy specimen revealed diffuse proliferation of large lymphoma cells expressing the activated helper/inducer T‐cell phenotype (LCA + , UCHL1 + , OPD4 + , LN3 + , MT1 ‐ , L26 ‐ , MB1 ‐ , Leu M1 ‐ , Ki‐1 ‐ KP1 ‐ ). The lymphoma was successfully treated by chemotherapy and irradiation. Intractable thrombocytopenia provoked fatal esophageal hemorrhage. At autopsy, no lymphomatous lesion was identified, and the hepatic right lobe contained an encapsulated necrotic lesion with‐out any viable tumor cells. The bone marrow revealed marked hyperplasia of erythroid and megakaryocytic series. Extramedullary hematopoiesis was demonstrated in the liver, spleen and lymph nodes. This is the second case of primary hepatic T‐cell lymphoma associated with SLE.