Open AccessImmunohistochemical Study of Fiber Types in Human Extraocular Muscles
Author(s) -
Fujii Yoshiyuki,
Abe Junichi,
Nunomura Shinsaku,
Moriuchi Tsuyoshi,
Hizawa Kazuo
Publication year - 1990
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1990.tb02493.x
Subject(s) - extraocular muscles , tonic (physiology) , fiber type , immunohistochemistry , chemistry , anatomy , antibody , pathology , fiber , myosin , biology , medicine , immunology , endocrinology , biochemistry , organic chemistry
Fiber types in human extraocular muscle (h‐EOM) were examined immunohistochemicaliy with antibodies against slow tonic (anti‐ALD) and slow twitch (anti‐SOL) myosins. Four types of muscle fiber in h EOM were distinguishable according to their reactivities with these antibodies. Groups 1 and 2 fibers reacted with both antibodies, group 1 fibers showing stronger reactivity than group 2 fibers with anti‐ALD. Group 3 fibers reacted only with anti‐SOL. Group 4 fibers did not react with either antibody. The latter were the most common, and were the main fibers in both the peripheral (outer orbital) and central zones of h EOM. The next most common were group 1 fibers, which were located mainly in the peripheral layer. Group 2 fibers were less common, but were the second most common type in the central layer. Group 3 fibers were only minor constituents. Multiple innervations were observed in some fibers of groups 1 and 2, and group 1 fibers were suggested to be slow tonic myofibers in h‐EOM. These specific immunohistochemical and physiological features of h‐EOM seem to be the basis of the low morbidity seen in the usual types of muscular dystrophy. Acta Pathol Jpn 40: 808‐814, 1990.