Open AccessStudy of Vimentin Expression in Non‐Hodgkin's Lymphoma Using Paraffin Sections
Author(s) -
Tamaru Junichi,
Mikata Atsuo,
Itami Makiko,
Takagi Toshiyuki
Publication year - 1990
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1990.tb01594.x
Subject(s) - vimentin , immunoperoxidase , pathology , lymphoma , b cell , immunohistochemistry , mycosis fungoides , biology , medicine , monoclonal antibody , antibody , immunology
Human non‐Hodgkin's lymphomas were studied by means of an avidin biotin complex immunoperoxidase method using several monoclonal antibodies against the intermediate filament protein, vimentin. The study cases were 61 B cell lymphomas (including 2 plasmacytomas) and 30 T cell lymphomas (including 8 cases of mycosis fungoides). Twelve of the 61 B cell lymphomas were positive for vimentin, and were composed of extrafollicular center cells such as immunoblastic and plasmacytoid cells. On the other hand, lymphomas of follicular center cell origin were negative for vimentin. All cases of T cell lymphoma except for 14 (all of 9 AlLD‐ type lymphomas, all of 4 lymphoblastic lymphomas and one diffuse mixed small/ large lymphoma) were positive for vimentin. Although vimentin expression appeared to be influenced by various conditions such as the proportion of T‐ and B cell subsets, or B cell proliferation rate, follicular center cells were constantly negative for vimentin.