Open AccessGlial Fibrillary Acidic Protein Immunoreactivity of Chondrocytes in Immature and Mature Teratomas
Author(s) -
Notohara Kenji,
Hsueh Chao Liang,
Awai Michiyasu
Publication year - 1990
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1990.tb01570.x
Subject(s) - glial fibrillary acidic protein , gfap stain , vimentin , cartilage , immunostaining , pathology , immunohistochemistry , intermediate filament , biology , anatomy , chemistry , medicine , cytoskeleton , cell , genetics
The immunoreactivity of chondrocytes for glial fibrillary acidic protein (GFAP), other intermediate filament proteins and S‐100 protein was studied in formalin‐fixed paraffin‐embedded sections. A total of 95 cartilage specimens were examined from five immature teratomas, 12 mature teratomas, and a teratocarcinoma. GFAP‐immunoreactive chondrocytes were abundant in immature cartilages, and as the cartilages maturated, these chondrocytes decreased and became distributed peripherally. Elastic cartilage had more GFAP‐immunoreactive chondrocytes than non‐elastic cartilage. GFAP‐immunoreactive cartilage was often located close to central nervous tissue. lmmunostaining for vimentin and S‐100 protein revealed extensive distribution of immunoreactive chondrocytes in immature and mature cartilages, but in mature cartilage, chondrocytes at the center had less vimentin immunoreactivity. GFAP‐immunoreactive chondrocytes also showed apparent immunostaining for vimentin. There was no difference in immunohistochemical staining for the α and α subunits of S‐100 protein. The immunoreactivities of teratoma cartilage specimens were quite similar to those of respiratory tract cartilage.