Open AccessNeuroendocrine Differentiation in a Case of Acinic Cell Carcinoma of the Parotid Gland
Author(s) -
Ito Kunihisa,
Kakudo Kennichi,
Mori Ichiro,
Horiuchi Masatoshi,
Osamura Yoshiyuki
Publication year - 1990
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1990.tb01562.x
Subject(s) - acinic cell carcinoma , pathology , parotid gland , immunohistochemistry , cell , electron microscope , salivary gland , biology , carcinoma , anatomy , medicine , mucoepidermoid carcinoma , physics , optics , genetics
We report a case of acinic cell carcinoma of the parotid gland with neuroendocrine differentiation. Light microscopically, the tumor appeared as clear cell‐type acinic cell carcinoma. In addition, the tumor showed neurosecretory features such as Grimelius positivity and the presence of neurosecretory granules by electron microscopy. We suggest that a tumor cell arising from a stem cell can show simultaneous differentiation to both neuroendocrine and acinic cells.