Open AccessFormation of Nerve Twig‐like Nests and Schwannoma in an Unusual Case of Neurofibroma
Author(s) -
Yamamoto Osamu,
Suenaga Yoshinori,
Imayama Shuhei,
Horie Akio
Publication year - 1990
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1990.tb01543.x
Subject(s) - neurofibroma , schwannoma , twig , pathology , anatomy , medicine , neurofibromatosis , traditional medicine
A case of unusual neurofibroma in an 18‐year‐old Japanese male is reported. The histology of the tumor was characterized by nerve twig like nests intermingled with fascicular bundles. In the central portion, the tumor also contained a lobular lesion showing features characteristic of schwannoma. Immunohistochemically, the tumor cells in both the nests and the lobular lesion demonstrated a mostly positive reaction for S 100 protein. S 100 protein‐positive and negative cells were observed in equal numbers in the fascicular bundles surrounding the nests. This unusual nerve sheath tumor in which the S 100 protein positive cells form both nerve twig‐like nests and lobular schwannoma has not been reported previously. The origin of the S 100 protein‐positive cells in the two lesions is also discussed. Acta Pathol Jpn 40: 775‐779, 1990.