Open AccessExpression of T‐cell Receptor (TCR)α Chain on Normal Human Tonsils and T‐cell Lymphomas
Author(s) -
Masunaga Atsuko,
Baba Naoko,
Kin Shutaku,
Mori Shigeo
Publication year - 1990
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1990.tb01536.x
Subject(s) - t cell receptor , pathology , t cell , cell , palatine tonsil , biology , microbiology and biotechnology , medicine , immunology , genetics , immune system
We analyzed immunohistologically the expression of T cell receptor (TCR)α chain on human tonsils and on T cell lymphoma (T ML) tissues using the avidin biotin peroxidase method. A murine monoclonal antibody αF1, specific for the constant region of the JCRα chain, was employed. On normal tonsil, αF1 positive cells were observed mainly in T zones and germinal centers. In T zones, the staining intensities varied markedly, with heavy staining evident in less than one fourth. In germinal centers, a proportion of stained cells showed a histiocytic pattern with small cytoplasmic projections. All the T ML tissues expressed TCRα, whereas the staining intensities varied among cases and among lymphoma cells. No correlations were observed in the expressions of TCRα chain and other T‐cell markers including CD3, CD4 and CD8. Acta Pathol Jpn 40: 722‐728, 1990.