Open AccessPulmonary Alveolar Proteinosis and Disseminated Atypical Mycobacteriosis in a Patient with Busulfan Lung
Author(s) -
Watanabe Kentaro,
Sueishi Katsuo,
Tanaka Kenzo,
Nagata Nobuhiko,
Hirose Nobuyuki,
Shigematsu Nobuaki,
Miake Shunji,
Yoshida Minoru
Publication year - 1990
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1990.tb01530.x
Subject(s) - pulmonary alveolar proteinosis , busulfan , pathology , autopsy , medicine , lung , pulmonary fibrosis , fibrosis , disease , hematopoietic stem cell transplantation
A 32‐year‐old Japanese man with chronic granulocytic leukemia died of respiratory failure. Autopsy revealed alveolar proteinosis and pulmonary fibrosis, complicated by disseminated atypical mycobacteriosis. Epithelial hyper‐plasia caused by busulfan therapy was probably responsible for the induction of excessive surfactant production, resulting in alveolar proteinosis, and the immunosuppres‐sive state due to chronic granulocytic leukemia was probably related to the induction of disseminated atypical mycobacteriosis. Acta Pathol Jpn 40: 63–66, 1990.