Open AccessPathology of the Liver in “Idiopathic Portal Hypertension” Associated with Autoimmune Disease
Author(s) -
Nakanuma Yasuni,
omura Akitaka,
Hayashi Morimoto,
Doishita Kenji,
Takayanagi Nobutatsu,
Uchida Toshikazu,
Obata Yutaka,
Noma Kenji,
Ikoma Jiro,
Yoshikawa Kazuhiko,
Umeyama Kaoru,
Oouchi Kiyoaki,
Yoshida Keisuke,
Ashida Hiroshi,
Ishikawa Yoshio,
Sugimachi Keizo,
Motojima Jiryuu,
Hanai Shiro,
Kameda Haruo
Publication year - 1989
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1989.tb02488.x
Subject(s) - pathology , portal hypertension , medicine , disease , cirrhosis
The histopathology of the liver in idiopathic portal hypertension (IPH) associated with autoimmune disease (15 cases), was examined and compared with that of IPH without autoimmune disease (31 cases). It was found that hepatic histopathology was heterogeneous in the cases with autoimmune disease. That is, the hepatic histopathology in 7 cases was similar to that of classic IPH without autoimmune disease, and the remaining 8 cases disclosed unusual lesions such as focal non suppurative cholangitis, nodular parenchymal hyperplasia, moderate portal inflammation, and intrahepatic ductopenia. These unusual lesions, which frequently coexisted in the same case, were not typical ones for making other diagnoses such as primary biliary cirrhosis or nodular regenerative hyperplasia of the liver. These findings suggest that unusual histologic lesions in the livers of IPH patients with autoimmune disease may represent an accentuated immunologic reaction inherent in IPH, or that such cases may be an abortive or incomplete form of primary biliary cirrhosis or nodular regenerative hyperplasia of the liver. Acta Pathol Jpn 39: 586‐592, 1989.