Open AccessAn Autopsy Case of So‐called Midline Malignant Reticulosis Followed by Extensive Dissemination with Immunohisto‐chemical Evidence for Its T Cell Malignancy
Author(s) -
Ohta Yoshihide,
Shimamura Kazuo,
Lertprasertsuke Nirush,
Horiuchi Masatoshi,
Osamura R. Yoshiyuki
Publication year - 1989
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1989.tb02460.x
Subject(s) - autopsy , pathology , malignancy , immunohistochemistry , infiltration (hvac) , monoclonal antibody , staining , medicine , biology , antibody , immunology , physics , thermodynamics
An autopsy case of malignant midline reticulosis (MMR) is reported. The patient, a 42 year old Japanese male, died after a clinical course of 22 months. Autopsy revealed extensive infiltration of generalized organs by the tumor cells, suggesting that the disease was highly malignant in nature. Staining with monoclonal antibodies against T cell surface antigens Leu 4 on frozen sections and UCHL1 on paraffin embedded sections enabled us to examine the phenotype of the tumor cells with good morphological preservation and to verify the T cell nature of the tumor. Acta Pathol Jpn 39: 446 450, 1989.