Open AccessTwo Familial Cases of Jordans' Anomaly: Ultrastructural Studies and the Development of Fat‐containing Vacuoles in the Neutrophilic Series
Author(s) -
Adachi Hironobu,
Yumoto Tokichi,
Takeda Lsamu,
Ozaki Masaharu,
Matsumoto Noboru,
Ishihara Tokuhiro,
Uchino Fumiya
Publication year - 1989
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1989.tb01509.x
Subject(s) - vacuole , organelle , staining , ultrastructure , pathology , chemistry , biology , microbiology and biotechnology , cytoplasm , medicine
A study was conducted on two brothers with Jordans' anomaly. Fat containing vacuoles were noticed in all leukocytes of the peripheral blood and cells of the myeloid series including myeloblasts, but the serum lipids showed no abnormalities. However, cells of the erythroid series, megakaryocytes and platelets did not contain these vacuoles. An increase in vacuole number was observed as the leukocytes matured. Histochemically, it was suggested that these vacuoles contained neutral fat based on staining with Sudan III and Nile blue sulfate. Ultra‐structurally, these vacuoles were unassociated with lysosomes or other cell organelles. Although the etiology of Jordans' anomaly could not be clarified by this study, genetic factors may be involved. Acta Pathol Jpn 39: 254 259, 1989.