Open AccessCombined Choriocarcinoma and Adenocarcinoma of the Lung
Author(s) -
Adachi Hironobu,
Aki Toshiaki,
Yoshida Haruhiko,
Yumoto Tokichi,
Wakahara Hideo
Publication year - 1989
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1989.tb01493.x
Subject(s) - choriocarcinoma , adenocarcinoma , carcinoembryonic antigen , pathology , cytokeratin , chorioepithelioma , human placental lactogen , human chorionic gonadotropin , lung , adenocarcinoma of the lung , immunohistochemistry , medicine , keratin 7 , lymph , trophoblast , keratin , placenta , biology , pregnancy , cancer , fetus , hormone , genetics
Combined choriocarcinoma and adenocarcinoma in the lung of a 71‐year‐old Japanese male is reported. In the upper lobe of the right lung (S1+ 2), a choriocarcinoma coexisted with an adenocarcinoma, but distinct metastatic lesions were noticed separately in the lungs, kidney, bone marrow and lymph nodes. Although immunohistochemical examination revealed intensely positive reactivity with anti‐human chorionic gonadotropin (HCG) in trophoblastic cells, weak immunoreactivities were also observed in a few cells with anti‐human placental lactogen (HPL), anti‐pregnancy specific β glycoprotein (SPI), anti‐epithelial membrane antigen (EMA), anti‐carcinoembryonic antigen (CEA), anti cytokeratin (keratin) and KM‐93 (lung adenocarcinoma‐associated antibody). In the adenocarcinoma, the tumor cells were positively stained for CEA, EMA, keratin and KM‐93, but there were no positive reactivities for HCG, HPL and SPI. These findings suggest that primary choriocarcinoma of the lung may arise through dedifferentiation of adenocarcinoma.