Open AccessDETERIORATION OF B CELL PROLIFERATION CORRELATES WITH DENDRITIC RETICULUM CELL DESTRUCTION IN GERMINAL CENTERS OF AN AIDS PATIENT. Case Study
Author(s) -
Mori Shigeo,
Ezaki Yukiyoshi,
Mori Mayumi,
Takahashi Muneharu,
Teshima Mari,
Sagawa Kimitaka
Publication year - 1988
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1988.tb02392.x
Subject(s) - germinal center , lymph node , antigen , pathology , cell , human immunodeficiency virus (hiv) , immunology , virology , b cell , biology , medicine , antibody , genetics
A lymph node from a bisexual Caucasian male infected with human immunodeficiency virus (HIV) and in the persistent generalized lymphadenopathy (PGL) stage was studied. Dendritic reticulum cells (DRCs) were well preserved in over half of the germinal centers (GCs), while in the rest, they showed marked destruction, producing patchy or rather wide DRC‐depleted areas. Proliferation‐associated antigens, i.e., PC antigen and DNA‐polymerase a, were demonstrated in nuclei of germinal center B cells in areas where the DRC network was intact, while they were prominently depleted in areas where the DRC network was lost. The p‐24 viral core antigen was shown to be localized in DRCs, especially those in the process of degeneration. These results suggest that the DRC in this patient, when infected with HIV, were destroyed, and that the resulting DRC depletion led to the suppression of B cell proliferation in GCs. ACTA PATHOL JPN 38: 1205∼1214, 1988.