Open AccessHAMARTOMATOUS SOLITARY POLYP WITH MALIGNANT PROGRESSION IN THE JEJUNUM. A Histochemical and Immunohistochemical Study by Light and Electron Microscopy
Author(s) -
Aneiros J.,
Matamala M.,
Del Moral R. Garcia,
Lopez J.J.,
Aguilar D.,
Camara M.
Publication year - 1988
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1988.tb02375.x
Subject(s) - carcinoembryonic antigen , pathology , immunohistochemistry , columnar cell , jejunum , mucus , biology , electron microscope , ultrastructure , goblet cell , epithelium , medicine , endocrinology , cancer , physics , ecology , genetics , optics
A case of solitary hamartomatous jejunal polyp with adenomatous and carcinomatous changes in a 16‐year‐old girl is reported. In the hamartomatous polyp, neutral and acid non‐sulfate mucosubstance was detected, principally in goblet cells; carcinoembryonic antigen was demonstrated on the surfaces of the microvilli and luminal border of the crypts and glands; absorptive columnar, goblet, argentaffin, argyrophil and Paneth cells were evident. The adenomatous and, mainly, the carcinomatous areas revealed a decreased amount of mucosubstance and a variable degree of positive intracytoplasmic staining for carcinoembryonic antigen. With electron microscopy, the adenomatous areas showed columnar absorptive cells and mucus‐secreting goblet cells; also immature columnar cells were observed in the dysplastic zones. To our knowledge, this is the first study to document the histochemical, immunohistochemical and ultrastructural features of a hamartomatous polyp with neoplastic transformation. ACTA PATHOL JPN 38: 1031∼1040, 1988.