Open AccessEXPERIMENTAL ACTIVATION OF LATENT CYTOMEGALOVIRUS INFECTION OF THE CAPTIVE BRED (F 1 ) CYNOMOLGUS MONKEYS BY LIVE OR KILLED VARICELLA‐ZOSTER VIRUS INOCULATED UNDER IMMUNOSUPPRESSION
Author(s) -
Ohtaki Sachi,
Hondo Ryo,
Kodama Hideo,
Kurata Takeshi
Publication year - 1988
Publication title -
acta patholigica japonica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.73
H-Index - 74
ISSN - 0001-6632
DOI - 10.1111/j.1440-1827.1988.tb02369.x
Subject(s) - immunosuppression , virology , cytomegalovirus , virus , biology , inoculation , herpesviridae , immunology , viral disease
F 1 cynomolgus monkeys bred in captivity and thought to be “SPF” had latent cytomegalovirus (CMV) infection although less frequently than in wild‐born monkeys. Latent CMV could be activated under severe immunosuppression by Inoculation with a certain strain of varicella‐zoster virus (VZV) as shown in a previous study. 1 We carried out further experiments using live and formalin‐inactivated VZV in F 1 monkeys which were sero‐positive for CMV, but not for any other viruses. The results showed that both live and inactivated VZV were equivalent in permitting activation of latent CMV, suggesting that the VZV inoculum merely played an immunogenic, but not any virological, role in this case. Captive F 1 monkeys, however, carried fewer CMV, and/or resisted CMV reactivation more than the wild monkeys in the previous studies, 1 judging from the time required for generalized CMV infection to become expressed. ACTA PATHOL JPN 38: 967∼978, 1988.